Alessandra Biffi Selected Research

Cerebroside-Sulfatase (Arylsulfatase A)

1/2021	Toward Reference Intervals of ARSA Activity in the Cerebrospinal Fluid: Implication for the Clinical Practice of Metachromatic Leukodystrophy.
7/2016	Lentiviral haemopoietic stem-cell gene therapy in early-onset metachromatic leukodystrophy: an ad-hoc analysis of a non-randomised, open-label, phase 1/2 trial.
1/2014	A new analytical bench assay for the determination of arylsulfatase a activity toward galactosyl-3-sulfate ceramide: implication for metachromatic leukodystrophy diagnosis.
8/2013	Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophy.
10/2009	Characterization of new arylsulfatase A gene mutations reinforces genotype-phenotype correlation in metachromatic leukodystrophy.
9/2006	Somatic intragenic recombination of the arylsulfatase A gene in a metachromatic leukodystrophy patient.

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Alessandra Biffi Research Topics

Disease

11	Metachromatic Leukodystrophy (Sulfatide Lipidosis) 01/2021 - 04/2004
6	Disease Progression 10/2021 - 04/2009
6	Globoid Cell Leukodystrophy (Krabbe Disease) 12/2019 - 03/2009
5	Mucopolysaccharidosis I (Hurler Syndrome) 05/2022 - 12/2010
4	Infections 01/2022 - 11/2009
4	Neoplasms (Cancer) 10/2021 - 08/2019
4	Lysosomal Storage Diseases (Lysosomal Storage Disease) 06/2015 - 08/2013
3	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/2022 - 08/2019
3	Anaplastic Large-Cell Lymphoma (Ki 1 Lymphoma) 02/2021 - 01/2020
3	Pneumonia (Pneumonitis) 01/2021 - 03/2020
3	Multiple Sulfatase Deficiency Disease (Mucosulfatidosis) 08/2010 - 04/2007
2	Chronic Granulomatous Disease 01/2022 - 01/2016
2	Hematologic Neoplasms (Hematological Malignancy) 01/2021 - 01/2018
2	Adrenoleukodystrophy (Adrenoleukodystrophy, X-Linked) 12/2019 - 04/2011
2	Wiskott-Aldrich Syndrome 12/2019 - 08/2013
2	Inborn Genetic Diseases (Disease, Hereditary) 10/2019 - 01/2019
2	Sickle Cell Anemia (Hemoglobin S Disease) 01/2019 - 10/2018
2	Metabolic Diseases (Metabolic Disease) 01/2018 - 10/2017
2	Neuroinflammatory Diseases 10/2017 - 04/2009
2	Brain Diseases (Brain Disorder) 01/2014 - 12/2010
2	beta-Thalassemia (Cooley's Anemia) 05/2010 - 11/2009
1	Leukemia 03/2022
1	Pain (Aches) 03/2022
1	Histiocytosis 01/2022
1	Cytochrome B-Negative Autosomal Recessive Chronic Granulomatous Disease 01/2022
1	Necrotizing Pneumonia 01/2022
1	Thrombocytopenia (Thrombopenia) 01/2022
1	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL) 01/2022
1	Macrophage Activation Syndrome 01/2022
1	Adenoviridae Infections (Adenovirus Infections) 12/2021
1	Carcinogenesis 02/2021
1	Acute-Phase Reaction 02/2021
1	Colitis 01/2021
1	Hodgkin Disease (Hodgkin's Disease) 01/2021
1	Neurologic Manifestations (Neurological Manifestations) 01/2021
1	Burkitt Lymphoma (Burkitt's Lymphoma) 01/2021
1	Vision Disorders (Hemeralopia) 01/2021
1	Communicable Diseases (Infectious Diseases) 01/2021
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2021
1	Glioblastoma (Glioblastoma Multiforme) 10/2020
1	Fever (Fevers) 03/2020
1	Adrenal Insufficiency (Adrenal Gland Hypofunction) 01/2020
1	Sclerosis 01/2020
1	Severe combined immunodeficiency due to adenosine deaminase deficiency 12/2019
1	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 12/2019
1	Nervous System Diseases (Neurological Disorders) 06/2019
1	Thalassemia 01/2019
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2018
1	Muscular Dystrophies (Muscular Dystrophy) 01/2015

Drug/Important Bio-Agent (IBA)

6	EnzymesIBA 01/2022 - 09/2010
6	Cerebroside-Sulfatase (Arylsulfatase A)IBA 01/2021 - 09/2006
5	Lysergic Acid Diethylamide (LSD)IBA 05/2022 - 04/2009
5	Biomarkers (Surrogate Marker)IBA 02/2021 - 01/2021
5	GalactosylceramidaseIBA 06/2015 - 03/2009
4	Iduronidase (alpha-L-Iduronidase)IBA 05/2022 - 12/2010
4	Proteins (Proteins, Gene)FDA Link 01/2020 - 08/2013
3	Busulfan (Busulfex)FDA Link 05/2010 - 11/2009
2	Anti-Bacterial Agents (Antibiotics)IBA 01/2022 - 03/2020
2	GlycosaminoglycansIBA 02/2021 - 12/2010
2	MicroRNAs (MicroRNA)IBA 01/2021 - 11/2010
2	AntigensIBA 01/2020 - 11/2009
2	SulfatasesIBA 08/2010 - 04/2007
1	Adenosine Diphosphate (ADP)IBA 01/2022
1	SteroidsIBA 01/2022
1	Interleukin-7 (Interleukin 7)IBA 01/2022
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2022
1	NADPH Oxidases (NAD(P)H oxidase)IBA 01/2022
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2022
1	brincidofovirIBA 12/2021
1	DNA (Deoxyribonucleic Acid)IBA 10/2021
1	CollagenIBA 02/2021
1	TenascinIBA 02/2021
1	Anaplastic Lymphoma KinaseIBA 02/2021
1	OsteopontinIBA 02/2021
1	Biological ProductsIBA 02/2021
1	Lysine (L-Lysine)FDA Link 01/2021
1	MethyltransferasesIBA 01/2021
1	letermovirIBA 01/2021
1	venetoclaxIBA 01/2021
1	Coloring Agents (Dyes)IBA 10/2020
1	RNA (Ribonucleic Acid)IBA 01/2020
1	Adenosine DeaminaseIBA 12/2019
1	OligonucleotidesIBA 10/2019
1	GlobinsIBA 01/2019
1	Fetal Hemoglobin (Hemoglobin F)IBA 01/2019
1	Dinoprostone (PGE2)FDA Link 01/2018
1	Complementary DNA (cDNA)IBA 10/2016
1	Pioglitazone (Actos)FDA Link 01/2016
1	Protein Isoforms (Isoforms)IBA 01/2015
1	Laminin (Merosin)IBA 01/2015

Therapy/Procedure

13	Therapeutics 03/2022 - 04/2011
4	Drug Therapy (Chemotherapy) 03/2022 - 03/2020
4	Stem Cell Transplantation 12/2021 - 11/2009
4	Hematopoietic Stem Cell Transplantation 01/2020 - 04/2009
3	Transplantation 01/2021 - 04/2004
2	Cell Transplantation 10/2017 - 12/2010
1	Analgesia 03/2022
1	Precision Medicine 01/2022
1	Aftercare (After-Treatment) 08/2019
1	Investigational Therapies (Experimental Therapy) 01/2018